The HFMD outbreak in Southern Vietnam has become a significant public health concern in the early months of 2026. According to the national infectious disease surveillance system, Vietnam has recorded over 25,000 cases of Hand, Foot, and Mouth Disease, a fivefold increase compared to the same period last year. Notably, the Southern region accounts for more than 70% of these cases, prompting urgent medical interventions.
Why the HFMD outbreak in Southern Vietnam is causing severe cases
The primary reason behind the severity of the current HFMD outbreak in Southern Vietnam is the dominance of the Enterovirus 71 (EV71) strain. Recent laboratory results from the Pasteur Institute in Ho Chi Minh City indicate that approximately 56% of positive samples are linked to this specific strain. EV71 is known for its high virulence and its ability to directly attack the central nervous system, leading to dangerous complications such as encephalitis and acute pulmonary edema.
Furthermore, medical experts emphasize that 2026 falls within the natural epidemic cycle of the disease. The combination of this cycle and the aggressive nature of the EV71 strain has placed immense pressure on tertiary pediatric hospitals in Ho Chi Minh City and neighboring provinces.

Hand of a child infected with Enterovirus 71 virus
Emergency Directives: Official Dispatch No. 450/PB-BTN
In response to the escalating HFMD outbreak in Southern Vietnam, the Department of Preventive Medicine (Ministry of Health) issued Official Dispatch No. 450/PB-BTN on March 26, 2026. This document mandates that local healthcare authorities must prioritize three key areas:
* Enhanced Surveillance: Schools, nurseries, and kindergartens must be closely monitored to detect and isolate outbreaks early.
* Treatment Triage: Hospitals must organize efficient admission and referral protocols to avoid overcrowding and minimize the mortality rate.
* Logistics and Supplies: Ensuring an adequate supply of essential medicines, medical equipment, and disinfectants for both emergency care and prevention.
Warning Signs and Guidance for Parents
To effectively manage the HFMD outbreak in Southern Vietnam, the Ministry of Health advises parents to monitor their children for “warning signs.” Immediate medical attention is required if a child exhibits a persistent high fever, frequent startle reflexes (especially when lying down), shaky limbs, unsteady walking, or abnormal crying. Early intervention during the “golden window” is the most critical factor in saving lives during this outbreak.
Truong Phan Hong Ha – Center for Support & Continuing Education